General toxicity and genotoxicity studies of a new scale inhibitor for seawater desalination

Abstract Maleic acid polymer scale inhibitor is a new domestic seawater desalination inhibitor. This study tested the acute oral toxicity, sub-chronic toxicity and genotoxicity of this The LD 50 obtained from test was 6810 9260 mg/kg·BW for male female rats, as well 1/5, 1/10 1/20 were dose test. It showed weight rats with high significantly lower than control group during exposure period ( p < 0.05), food consumption in first 4 weeks _ week1 = 0.0261, week4 0.00222). blood biochemical results UREA medium- high-dose groups higher medium 0.0047, 0.0037; 0.0026, _high 0.001), increased dependence. Based on results, NOAEL LOAEL , respectively (males: 340.5 681 mg/kg·BW, females: 436 926 mg/kg·BW). Comet assay vitro Mammalian Erythrocyte Micronucleus Test jointly to judge genotoxicity. did not cause chromosome aberrations mouse bone marrow cells. However, tail moment CHO cell all 0.01) DNA% 1/4 IC negative 0.001) comet assay, suggesting potential DNA damage cell. provides theoretical basis further research risk assessment. Graphical